OncologyIstanbul
Guides · Treatment decisions

Ten questions to ask before agreeing to chemotherapy

Reviewed by Prof. Dr. Leyla Arslan
21 May 2026 · 6 min

Chemotherapy is a plan, not a single drug — and plans differ between hospitals more than most patients expect. These ten questions turn a prescription into a conversation.

The ten questions

Take them to the appointment on paper. A good oncologist answers all ten without irritation — that reaction is itself a data point:

01 · What is the goal — cure, control, or symptom relief? The honest answer shapes every other decision.
02 · Which protocol, by name — protocols have names and published evidence. Ask for both.
03 · Why this protocol for my receptors — the pathology report and the protocol must agree.
04 · How many cycles, how far apart — and what decides whether the count changes mid-course.
05 · What response will be measured, and when — which scan, after which cycle.
06 · The realistic side effects — the three most likely for this protocol, not the full leaflet.
07 · What is done to prevent them — pre-medication, growth factors, scalp cooling: prevention is part of the protocol.
08 · Can it be given closer to home — some cycles can transfer to a local clinic with the same protocol on paper.
09 · What happens if a cycle is delayed — illness and travel happen; the plan should already contain the answer.
10 · What would you do in my place — the question that separates a prescriber from a physician.
Protocol ≠ brand
The protocol — drugs, doses, schedule — is what the evidence supports. The brand of each drug can often change without changing the protocol. Ask about the protocol first; the brand question is a cost question.

“The patients who do best are not the ones who ask nothing and trust everything — they are the ones whose folder has ten questions written down and ten answers next to them.”

— Prof. Dr. Leyla Arslan, medical oncology
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Fair questions

Yes — that is the most common request we receive. Send the pathology report and the proposed protocol; the board confirms it, adjusts it, or explains why a different protocol fits your case better.
Every cancer case is individual. Assessments are based on the reports you provide and do not replace in-person examination.